Graham,
I don't know about Backup Now (or what it consists of), but I would take it out and see where that leaves you.
With reference to the last but one posting - if the drive was previously working, then I would expect to see /dev/nst0 even if something had happened in the interim, unless you had rebuilt the server (and I don't remember you saying you'd done that). If the SCSI adapter is OK, but the drive is faulty (or a connection is bad), then that would be one explanation for your problem. Did you check the connections? Boot with the drive disconnected from the adapter. Does /dev/nst0 still get identified?
Sorry I can't think of anything more right now.
Des Dougan