UPDATE:
My initial problem was I installed WordPress 3.x into /opt/ using SME Site Maker. I thought it would be more secure since it was installed in /opt (This is not really true, I think)
Thereafter, I activated MultiSite Network through my Wordpress install, and made several production sites using one MySQL Database.
This prevented me from being able to utilize the Domain Mapping Plugin, and multiple Cache Plugins.
I could redirect all http traffic to /opt/"wordpress" but all the pages created in the iBay that are not associated with WordPress would need to be redirected or proxypassed or whatever. It would be too difficult.
In order to move Wordpress 3.x Multi Site, I had to change the Domain URL and path in the config.php like mary said.
Additionally, I had to dump the SQL database, and do a search for ["domain.tld/wordpress" ; "/wordpress/" ; "domain.tld"] (where wordpress is whatever your alias and /opt/* file is named. The paths and urls are stored in the databse and must be changed.
Afterwards, I reloaded the SQL in a new database and change my config.php to be the new table (I never like to overwrite previously functional data. It's easier to delete after new data is functional).
Not sure about webapps contrib being operational for SME 8 x64, but I can say that SME Site Maker works superbly!
Final question, how would I do 301 redirects? Is it in .htaccess? I just want to make sure all my old URLs redirect to the new URL for the new wordpress location