Thank you for your replies. I can see the problems and extra work that will result from not just inheriting qpsmtpd from CentOS.
For me, one reason for raising the discussion has been that I see new problems showing up in the qpsmtpd log files: attacks where outside clients try thousands of different passwords for standard user names like "payments", "company" etc., with qpsmtpd just politely denying each new password. And problems with handling IPv6 connections, especially from linkedin.com .
Another reason is that after a long period of very low activity, a lot has been happening with qpsmtpd since 2012. I must admit that I'm not sure the new versions will handle the problems, I've been seeing, but it seems like all the effort from the qpsmtpd developers is focused on the newest versions.
Best,
Jesper