as told by Reetp there is no one size fit all and it is important for you to state what are the essential services and on wich coast they are and how you plan to failover if the main service is unreachable.
I mean if your main application is on a east coast computer and the vpn for roadwarriors to east coast is unreachable, chance are that the s2s is also down. so you need to have some sort of heartbeat or slave replication at least for read only consultation on the west coast when the s2s fails in order to have the service available. you also need some script to mod the vpn dns to point to the local west coast read only replica instead of the main on the east coast main service.
all of this is doable, but this is way more advance than the purpose of SME, while doable with SME, and will need some advanced skills to deploy it.
this is advance professional level service.