Doesn't appear that mod_perl is included (ls /etc/httpd/modules | grep perl) although I can't see why one can't install any apache module as long as the template files under /etc/e-smith/templates/etc/httpd/conf are also modified (in fact, it appears that the httpd.conf template has the mod_perl.c module commented out)
This is from E-Smith 3.0.3_1
HTH,
Billy
PS: remove nospam to reply ... gotta hate spammers ...