Nick,
What e-mail client are you using ?
If you are using MS-Outlook-whatever, consider changing to some other e-mail program.
Personally, I use Calypso. Although the original authors have given up further development of the product, I still find it a great e-mail client. Calypso stores your individual mail settings in a single file (called a mailbox). Like any other client, you can check multiple mail accounts, etc within one mailbox. In my case, I keep my mailbox in an I-Bay on the SME server. I can access the mailbox from any workstation that has Calypso installed and also has access to the I-Bay.
The standard SME backup does the rest.
Hope this is useful.
Kelvin