Greg,
In fact I'm using it. :>
The attraction of TMDA is that it uses a "whitelist" for accepting mail, rather than a "blacklist" which can never be fully current.
Known email addreses are entered into the "whitelist" and always accepted.
Mail sent to you from a new address is sent a polite response requesting a return confirmation and then is no longer blocked and from then on it can be accepted or blocked at will.
All spam gets the same polite message but is never read or returned and therefore no access.
The "blacklist" method makes me responsible for proactively and continually updating the always growing blacklist database. And as we all know, size matters :>
Cheers,
-Jeff