Sure... The config information for the proxypass is stored in one of 2 of the internal e-smith config databases. The ProxyPass for an individual directory info is stored in the "accounts" database (/home/e-smith/accounts). The ProxyPass for VirtualDomain info is added to the virtual domain's record in the "domains" database (/home/e-smith/domains).
From your description of the various options, I could tell that you had tried to update a specific directory on the main server, rather than a virtual domain.
So, the first step is to use the command line to delete the ProxyPass info from the "accounts" database. (/sbin/e-smith/db accounts.... )
Now that the config info has been removed, we need to force the server to rebuild all of the config files with the current config info. I'm sure you've come across other posts referring to the e-smith templates and templates-custom. When the templates are expanded, the system checks the config databases and builds the appropriate config files for each service.
Since 2 services were affected by our change (standard web services and the admin web services), we had to expand both of those templates using "/sbin/e-smith/expand-template...".
And finally, now that the httpd config files have been regenerated, we need to restart the httpd service to force it to re-read the config files.
Hope that helps a little.