I'm sorry to hear you have to use an NT mail server, but am delighted to hear our e-smith software referred to as "beloved"

A good solution to this problem has already been posted by Charlie Brady and Gordon Rowell.
Here are the steps:
1. Log into the e-smith console (Ctrl-Alt-F3, user "root" with the current system password).
2. Edit the file:
/etc/e-smith/templates/var/qmail/control/locals
and delete the two lines from it, leaving it a zero-length file.
3. Edit the file
/etc/e-smith/templates/var/qmail/control/smtproutes
and delete everything that's there, then replace it all with the following single line:
your.domain:[192.168.100.100]
and replace "your.domain" with your actual domain name and 192.168.100.100 with the IP address of your NT mail server.
4. Update the e-smith configuration by executing the following commands:
/sbin/e-smith/config set DomainName your.domain
/sbin/e-smith/config set SMTPSmartHost on
/sbin/e-smith/signal-event manager-misc
again replacing "your.domain" with your actual domain name.
5. Type "logout" and Ctrl-Alt-F1 to return to the main console.
With this configuration, the e-smith box will still be your server and gateway, but incoming mail will be forwarded to your NT box. Therefore you don't need to create individual user accounts on the e-smith box.
Good luck!
- Joe Morrison