I have quite a few SME 5.6 boxes out there. The "stock" standard installs are generally the most stable (except when they are running on really new hardware where the kernel does not recognise chipsets, etc).
On one fairly important production server, the users insist on using Webmail and not POP3 or IMAP. And, in order to overcome some problems with webmail that ships with SME 5.6, I had to install the updated PHP and Webmail (following the how-to on contribs) plus increase the allowed attachment size, etc, etc. No other add ins except for Arkeia backup (which I have running at ALL SME sites). This server has problems that's symptomatic of a memory leak (ie. works fine upon a reboot for days / weeks then suddenly get kernel out of memory errors, or mysqld shutsdown, etc, but mostly out of memory errors). A reboot clears up the problem until the cycle repeats. Putting in more RAM stretches out the time between reboots. I have replaced the entire system before (even moved it to another server that's been running 24x7 with SME 5.6 without hassles before) and the same symptoms and problem reoccurs. I now generally reboot the server every week or so (or after a few days if webmail's been used heavily) and the problem does not surface. If I leave it long enough, it comes back.
And it continues ....
Kelvin