Hi FSCITADMIN,
rest your worried soul! Between the simplicity of the SME Server Manager and the strength of this community(contribs.org, the sourceforge "gang" and many more) you do not have to be a *nix guru or a full-time admin. IMHO.
Q1). "second drive", are you trying to do a dual boot system? I would suggest to disconnect the first drive and install SME on its own drive. This will keep the original drive "un-touched".
Q2). Clean machine==new install? Put the SME cdrom in the cd drive, boot the computer, follow the prompts, and in about 1/2 hour you will be a server admin!
Q3). Major issues are always a possibilty but not likely. If you know what hardware you are going to be using, just do a search on the forum here. Attempt to install on what you have and see what happens. Post here if you need help.
Q4). SME is very powerful. How many people are you going to have on it? Will they all have mail? Do you need a web-site?
Q5). Redhat 7.3 to be precise. SME is ready to go "out of the box". The ties to RH 7.3 are more relevant for developing or customizing.
Q6). You login to the SME through any web browser (Firefox, IE, Opera, etc.). The SME, by design, does not need a gui, you administer it through the web based Server Manager Panel
Q7). Yes.
Q8).Back ups can be done in a number of ways on the SME. I use a tapedrive here, but the Back-up To Desktop feature is very easy to use and effective. Do a search of the forums for specific input.
Give it a try! There are a ton of great people involved on the SME. Post here on the forums and see where it goes.
Good Luck
Joe