I also think you would be struggling. Most NAS systems allow drives to shut down, and for them it is sensible, since there is little else going on other than disk access when a network user requests a file.
For SME, there is a lot more happening, such as virus scanning, e-mail checking, proxy serving etc.
Now, if you have managed to get this working with a USB-connected drive, I would be most interested. To get a backup to run to a USB drive each night, and have the drive shut down the rest of the time (powered down, that is, not just unmounted - and I'm not sure what protocols USB drives support in this area), would be a great benefit. If the backup drive is only running for half an hour each day, I think it would last far longer than if it were left on 24/7/52. If nothing else, it would draw less power.
-- JJ