OK, looking at the mail logs, sender statistics, there is a lot of spam going out from userID 400 - 406. The usernames for these are qmaild, qmaill, qmailp, qmailq, qmailr, and qmails. Also, UID 453, which is listed as qpsmtpd system user.
As SME is really only used as a mail server there are very few going from genuine users. None of the users log in to the server, only their e-mail clients have the login details for a user. Any further pointers appreciated.