For one, it means installing additional services and responsibilities on a Windows machine. I don't know if you've noticed or not, but the mail reason Windows performs so badly is that too much varied software gets installed on machines. The least amount of software on the client the better. Further, it prints to the local machine rather than through a remote machine. It is better on the server.
But with that said, is it possible to make the driver portion of PDF Creator communicate with the server side of the PDF printer? If so, then that is most definitely the answer. I know one avenue I am going to try exploring is using CutePDF in a similar fashion. Many of my CAD users like to make PDFs in a wide variety of paper sizes. CutePDF allows that... I haven't tested PDFCreator for that functionality but I will.