jookin,
Surely they are getting smarter - all the time. Tuning the spamfilter is a continuous job I am afraid. What I have done with success is to:
1) Enable DCC (/etc/mail/spamassassin/v310.pre)
2) Utilize the unofficial clamav signatures (
http://wiki.contribs.org/Email#Anti_Virus)
3) reject emails with score above 9 and tags above 5
4) install the server-manager module that allows whitelistning - sometimes its needed
If there are certain SA rules that creates the false positives then you might want to increase their score.