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Is the internal host an Exchange server ?
If so there is "desirable" functional interaction when using Delegation, see the Email FAQ or search forums on Exchange.
Otherwise you answered your own question.
" ...... completely disable SME's email...... make SME forward all traffic for port 25 to a host on the inside".
Although if you completely disable all of SME's mail system, you will not get any system generated messages. Just disable the smtp server with a db command & stop the service. Port 25 will then be closed and can then be port forwarded. I think that should be sufficient.