I can confirm that, it happened for me as well this morning after running that latest upgrade from terminal...
According to /var/log/qmail/current , it looks that clamav is stopping outgoing mail:
...snip...
@400000004f66fa242e93ca3c 14926 trying to get config for signatures_patterns
@400000004f66fa242ea07854 14926 Plugin virus::pattern_filter, hook data_post returned DECLINED,
@400000004f66fa242ea0fd24 14926 running plugin (data_post): tnef2mime
@400000004f66fa242f29b524 14926 Plugin tnef2mime, hook data_post returned DECLINED,
@400000004f66fa242f2a41c4 14926 running plugin (data_post): spamassassin
@400000004f66fa242f2ba53c 14926 spamassassin plugin (data_post): check_spam
@400000004f66fa242f33cb2c 14926 spamassassin plugin (data_post): check_spam: connected to spamd
@400000004f66fa242f3e7d74 14926 spamassassin plugin (data_post): check_spam: finished sending to spamd
@400000004f66fa293970fe84 14926 spamassassin plugin (data_post): check_spam: spamd: SPAMD/1.1 0 EX_OK
@400000004f66fa2939710a3c 14926 spamassassin plugin (data_post): check_spam: spamd: Content-length: 0
@400000004f66fa293971120c 14926 spamassassin plugin (data_post): check_spam: spamd: Spam: False ; 0.0 / 5.0
@400000004f66fa29397115f4 14926 spamassassin plugin (data_post): check_spam: spamd:
@400000004f66fa2939adec2c 14926 spamassassin plugin (data_post): check_spam: finished reading from spamd
@400000004f66fa2939adf7e4 14926 spamassassin plugin (data_post): check_spam: No, hits=0.0, required=5.0, tests=
@400000004f66fa2939adffb4 14926 Plugin spamassassin, hook data_post returned DECLINED,
@400000004f66fa2939ae0784 14926 running plugin (data_post): spamassassin
@400000004f66fa2939ae0b6c 14926 spamassassin plugin (data_post): check_spam_reject: reject_threshold=10
@400000004f66fa2939ae133c 14926 spamassassin plugin (data_post): check_spam_reject: score=0.0
@400000004f66fa2939ae692c 14926 spamassassin plugin (data_post): check_spam_reject: passed
@400000004f66fa2939ae70fc 14926 Plugin spamassassin, hook data_post returned DECLINED,
@400000004f66fa2939ae78cc 14926 running plugin (data_post): spamassassin
@400000004f66fa2939ae7cb4 14926 Plugin spamassassin, hook data_post returned DECLINED,
@400000004f66fa2939ae8484 14926 running plugin (data_post): virus::clamav
@400000004f66fa2939ae886c 14926 virus::clamav plugin (data_post): Changing permissions on file to permit scanner access
@400000004f66fa2939ae9fdc 14926 virus::clamav plugin (data_post): Running: /usr/bin/clamdscan --stdout --config-file=/etc/clamd.conf --no-summary /var/spool/qpsmtpd/1332148762:14926:0 2>&1
@400000004f66fa293b469d2c 14926 virus::clamav plugin (data_post): clamscan results: /var/spool/qpsmtpd/1332148762:14926:0: OK
@400000004f66fa293b46a8e4 14926 Plugin virus::clamav, hook data_post returned DECLINED,
@400000004f66fa293b46b0b4 14926 running plugin (queue): logging::logterse
...snip...
I managed to "solve" the problem temporarily by DISABLING clamav for mail on that server.....