I've successfully configured SME 10 to obtain a let's encrypt certificate, as per the wiki instructions. Yesterday (and today) I've got failure reports during attempts to renew the certificate (redacted, can PM the exact message):
# INFO: Using main config file /etc/dehydrated/config
Processing myhost.mydomain
 + Checking domain name(s) of existing cert... unchanged.
 + Checking expire date of existing cert...
 + Valid till Feb 22 09:35:15 2022 GMT (Less than 30 days). Renewing!
 + Signing domains...
 + Generating private key...
 + Generating signing request...
 + Requesting new certificate order from CA...
 + Received 1 authorizations URLs from the CA
 + Handling authorization for myhost.mydomain
 + 1 pending challenge(s)
 + Deploying challenge tokens...
 + Responding to challenge for myhost.mydomain authorization...
 + Cleaning challenge tokens...
 + Challenge validation has failed 
ERROR: Challenge is invalid! (returned: invalid) (result: ["type"]	"http-01"
["status"]	"invalid"
["error","type"]	"urn:ietf:params:acme:error:unauthorized"
["error","detail"]	"Invalid response from http://myhost.mydomain/.well-known/acme-challenge/y2C3vJWm4-sTlcFOJgu4ZYJ-oNGvhBx6vMUUHL3jabM [my.ip.add.ress]: \"\u003c!DOCTYPE HTML PUBLIC \\\"-//IETF//DTD HTML 2.0//EN\\\"\u003e\\n\u003chtml\u003e\u003chead\u003e\\n\u003ctitle\u003e403 Forbidden\u003c/title\u003e\\n\u003c/head\u003e\u003cbody\u003e\\n\u003ch1\u003eForbidden\u003c/h1\u003e\\n\u003cp\""
["error","status"]	403
["error"]	{"type":"urn:ietf:params:acme:error:unauthorized","detail":"Invalid response from http://myhost.mydomain/.well-known/acme-challenge/y2C3vJWm4-sTlcFOJgu4ZYJ-oNGvhBx6vMUUHL3jabM [my.ip.add.ress]: \"\u003c!DOCTYPE HTML PUBLIC \\\"-//IETF//DTD HTML 2.0//EN\\\"\u003e\\n\u003chtml\u003e\u003chead\u003e\\n\u003ctitle\u003e403 Forbidden\u003c/title\u003e\\n\u003c/head\u003e\u003cbody\u003e\\n\u003ch1\u003eForbidden\u003c/h1\u003e\\n\u003cp\"","status":403}
["url"]	"https://acme-v02.api.letsencrypt.org/acme/chall-v3/71559634970/xNPwug"
["token"]	"y2C3vJWm4-sTlcFOJgu4ZYJ-oNGvhBx6vMUUHL3jabM"
["validationRecord",0,"url"]	"http://myhost.mydomain/.well-known/acme-challenge/y2C3vJWm4-sTlcFOJgu4ZYJ-oNGvhBx6vMUUHL3jabM"
["validationRecord",0,"hostname"]	"myhost.mydomain"
["validationRecord",0,"port"]	"80"
["validationRecord",0,"addressesResolved",0]	"my.ip.add.ress"
["validationRecord",0,"addressesResolved"]	["my.ip.add.ress"]
["validationRecord",0,"addressUsed"]	"my.ip.add.ress"
["validationRecord",0]	{"url":"http://myhost.mydomain/.well-known/acme-challenge/y2C3vJWm4-sTlcFOJgu4ZYJ-oNGvhBx6vMUUHL3jabM","hostname":"myhost.mydomain","port":"80","addressesResolved":["my.ip.add.ress"],"addressUsed":"my.ip.add.ress"}
["validationRecord"]	[{"url":"http://myhost.mydomain/.well-known/acme-challenge/y2C3vJWm4-sTlcFOJgu4ZYJ-oNGvhBx6vMUUHL3jabM","hostname":"myhost.mydomain","port":"80","addressesResolved":["my.ip.add.ress"],"addressUsed":"my.ip.add.ress"}]
["validated"]	"2022-01-24T22:22:38Z")
Any idea on how to proceed from here?