I am experiencing the same kind of thing.
Admin account filling up with double bounce messages
and looping galore!
I’m not going to be too quick to place blame however;
this could be bad DNS MX, (no reverse or duplicates)
or other bad config.
The only data point I know for sure is the thing runs like a pig
with Spamassassin turned on and just fine with it off.
(Ver. 6.0.1 w/smeplus)